![]() ![]() Some forms of TiO2 nanoparticles induce mild intracellular oxidative stress and apoptosis (Horie et al., 2010). However, there are nonetheless some cellular effects Many cases, the cellular effects of these insoluble nanoparticles are less severe than those of soluble nanoparticles. Not include catalytic metals, do not release metal ions. Their metal ions into the medium (Horie et al., 2012a TiO2, CeO2, and platinum nanoparticles do not release However, not all nanoparticles release metal ions. Ion release, intracellular release induces severe cellularĮffects such as the induction of oxidative stress. Release metal ions within the cell (Horie et al., 2012b įukui et al., 2012). Nanoparticles are ingested into the cellsīy endocytosis, and then the internalized nanoparticles Release is the most important factor for predicting nanocytotoxicity. Respect to the in vitro cellular effects caused by nanoparticles (Horie et al., 2012b): metal ion release, cellularĬorrespondence: Masanori Horie (E-mail: 39 No. There are three important factors to evaluate with In the present study, we investigated the cellular effects caused by metal nanoparticlesĪnd nanocarbons, including gold (Au), silver (Ag), platinum (Pt), and hydrophilic carbon black (hCB). ![]() Therefore, understanding the toxicity of nanoparticles in their industrial forms is imperative.Īmong the nanoparticles, metal nanoparticles and nanocarbons are widely used. In addition, metal ions released from nanoparticles have been correlated to their cytotoxic activity For instance, nanoparticles exhibit high solubility compared to their micro-scale counterparts (Horie etĪl., 2009b). Properties also have biological influences that can be Nanoparticles have unique physical and chemical properties that are beneficial to industrial use. Currently, various kinds of nanoparticles are employed in many industries, including consumer products and the life sciences. Key words: Nanoparticle, Gold, Silver, Carbon black, Oxidative stressĪ nanoparticle is defined as a particle whose diameter Hence, the cellular effects of industrial nanoparticles should be evaluated carefully. In some cases, the dispersing agent may have caused some cellular effects.Īdsorption of agents on the surface of the nanoparticles may be an important factor here. Some nanoparticle dispersions included chemicals as the dispersant, which is The Pt nanopa rticles in this study contradicted our previous findings, in which Pt did not produce chemically reactive molecules. The observed increase in the ROS level induced by Hydrophilic carbon black did not exhibit any effects. The exposure to Pt nanoparticles inducedĪn increase in the intracellular reactive oxygen species (ROS) level. The exposure to Au and Ag decreased mitochondrial activity. The mitochondrial activity (MTT assay) and the induction of cellular oxidative stress were examined. Medium of human keratinocyte (HaCaT) and human lung carcinoma (A549) cells for 6 and 24 hr. ![]() Stable nanoparticle dispersions were prepared and applied to the culture (Received AugAccepted October 28, 2014)ĪBSTRACT - The effects of five types of metal nanoparticles, gold (Au), silver (Ag), platinum (Pt),Īu-polyvinylpyrrolidone (PVP) colloid, and Pt-PVP colloid, and two types of hydrophilic carbon black Health Research Institute (HRI), National Institute of Advanced Industrial Science and Technology (AIST),Ģ217-14 Hayashi-Cho, Takamatsu, Kagawa 761-0395, JapanĢNational Metrology Institute of Japan, AIST, 1-1-1, Higashi, Tsukuba, Ibaraki 305-8565, JapanģTechnology Research Association for Single Wall Carbon Nanotubes (TASC), AIST Tsukuba West,ġ6-1, Onogawa, Tsukuba, Ibaraki 305-8569, JapanĤResearch Institute of Science for Safety and Sustainability (RISS), AIST, 16-1, Onogawa, Tsukuba, Ibaraki 305-8569, JapanĥResearch Institute of Instrumentation Frontier (RIIF), AIST, 1-1-1 Umezono, Ibaraki 305-8568, JapanĦFaculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan Kazuhiro Yamamoto5, Shinichi Kinugasa2, Yoshihisa Hagihara1, Yasukazu Yoshida1 Lilian Kaede Komaba1, Keiko Nishio1, Ayako Nakamura2, Arisa Miyauchi3, Masanori Horie1, Haruhisa Kato2, Shigehisa Endoh3, Katsuhide Fujita4, Sci.)Ĭellular effects of industrial metal nanoparticles and The Journal of Toxicological Sciences (J. ![]()
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